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What is methadone?

Methadone is a prescription drug, and is part of a group of drugs known as opioids. Opioids interact with opioid receptors in the brain and elicit a range of responses within the body; from feelings of pain relief, to relaxation, pleasure and contentment.1

Methadone is taken as a replacement for heroin and other opioids as part of treatment for dependence on these drugs. Replacing a drug of dependence with a prescribed drug in this way is known as pharmacotherapy. As well as improving wellbeing by preventing physical withdrawal, pharmacotherapy helps to stabilise the lives of people who are dependent on heroin and other opioids, and to reduce the harms related to drug use.2

Methadone is also used to relieve pain following heart attacks, trauma and surgery.

Slang names

Done, ‘the done’.

Other types of commonly used opioids

MethadoneFact Sheet353.1 kbPDF

How is it used?

The Victorian pharmacotherapy program uses the syrup form of methadone. There are 2 brands of this liquid: Methadone Syrup® and Biodone Forte®.Generally, there are 2 types of methadone programs:

  • Maintenance (long-term programs): May last for months or years, and aim to reduce the harms associated with drug use and improve quality of life.
  • Withdrawal (short-term detoxification programs): Run for approximately 5-14 days and aim to ease the discomfort of stopping the use of heroin.4

For pain relief methadone is administered through an injection or tablets.

How effective is it?

Methadone treatment is more likely to be successful if it is part of a comprehensive treatment program, which addresses the body, mind and environment in which heroinhas been used.

For example, treatment may include a combination of methadone, counselling, alternative therapies and the development of a positive support network of peers, friends and a support group.5

Methadone maintenance may not work for everyone, so it is important to work with a doctor or drug counsellor to find the best approach.

Advantages of methadone maintenance over heroin use

  • Using methadone on its own is unlikely to result in an overdose.
  • Methadone maintenance keeps the person stable while they make positive changes in their life.
  • Health problems are reduced or avoided, especially those related to injecting, such as HIV, hepatitis B and hepatitis C viruses, skin infections and vein problems.
  • Doses are required only once a day, sometimes even less often, because methadone’s effects are long lasting.
  • Methadone is much cheaper than heroin.5

Effects of methadone

There is no safe level of drug use. Use of any drug always carries some risk – even medications can produce unwanted side effects. It’s important to be careful when taking any type of drug.

Methadone affects everyone differently, based on:

  • size, weight and health
  • whether the person is used to taking it
  • whether other drugs are taken around the same time
  • the amount taken.

The effects of methadone last much longer than the effects of heroin. A single dose lasts for about 24 hours, whereas a dose of heroin may only last for a couple of hours.6

People with pre-existing impaired liver function (due to conditions such as hepatitis B, hepatitis C or prolonged alcohol use) may require careful monitoring while receiving methadone treatment.7

Side effects

The most common side effects of methadone are:

  • sweating (drink at least 2 litres of water each day to prevent dehydration)
  • difficulty passing urine
  • loss of appetite, nausea and vomiting
  • abdominal cramps
  • constipation
  • aching muscles and joints
  • irregular periods
  • low sex drive
  • rashes and itching
  • lethargy, mental clouding and confusion.7

Dose-related effects

Some people on methadone programs will experience unwanted symptoms during their treatment due to their dosage not being right for them. This occurs particularly at the beginning of treatment.7

If the dose is too low, the following symptoms may be experienced:

  • runny nose
  • yawning
  • high temperature but feeling cold and sweating with goosebumps
  • irritability and aggression
  • loss of appetite, nausea and vomiting
  • abdominal cramps and diarrhoea
  • tremors, muscle spasms and jerking
  • back and joint aches
  • cravings for the drug they were dependant on.1


If the dose is too high, the following symptoms may be experienced. Call an ambulance straight away by dialling triple zero (000) if you have any of these symptoms (ambulance officers don’t need to involve the police):

  • depressed breathing, stupor or coma due to accumulation of the drug
  • severe constipation with obstruction of the bowel, or inability to pass urine
  • marked allergic reaction, with swelling of the face, lips, tongue and throat, wheezy breathing or tight chest
  • intense red rash with itching or hives
  • collapse.1

Long-term effects

Methadone in its pure form will not cause damage to the major organs of the body. Prolonged use of methadone will not cause any physical damage.


Methadone withdrawal develops more slowly and is less intense than withdrawal from heroin. Withdrawal symptoms are similar to those listed under ‘Dose-related effects’ under ‘too low’ dose. Most of these effects will begin within 1 to 3 days after the last dose and will peak around the 6th day, but can last longer.1

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Order methadone online is a unique opioid that may provide several important potential benefits for the patient in the perioperative period. It is a potent μ-receptor agonist with a rapid onset (6–8 minutes) and the longest half-life (24–36 hours) of the clinically-used opioids.2 

When used in larger doses, the clinical effect is terminated by systemic elimination. As reviewed in an editorial by Evan Kharasch,

methadone dosing should be as high as possible above the minimal analgesic concentration, but below the threshold for respiratory depression; at doses of ≥ 20 mg, the duration of analgesia approximates the half-life of 24 to 36 hours. Click Order Methadone online to get your treatment.

Order Methadone Online, the most effective treatment for heroin dependence

Methadone is a synthetic drug that acts like drugs derived from the opium poppy (“opioids”). It is well absorbed when swallowed in a single dose, lasting about 24 hours.

Methadone is used mainly to treat heroin dependence, but also dependence on other opioid prescription drugs. It is sometimes used to treat severe chronic pain.

The drug is legal, can be taken by mouth and once-daily doses make it easy to supervise. It is used in over 80 countries. In about half of these, methadone treatment is provided in prisons.

In 2015, Australia had over 48,000 people on opioid substitution treatment. The number is increasing by about 5% a year.

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How it works

After methadone attaches to the opiate receptors in the brain, many functions in the body are initially slowed (such as breathing and bowel movements) and pain is decreased. Later, the body learns to “tolerate” methadone, so the effects decrease.

Methadone is very soluble in fat and this makes absorption after swallowing very rapid. Methadone quickly enters the body’s fatty tissues,

which slowly release it after methadone levels in the bloodstream start dropping. This is what makes methadone last so long. you can equally order methadone online

People who take heroin after having taken an adequate dose of methadone for a couple of weeks will feel little or no effect of the heroin. Higher methadone doses for longer periods achieve better outcomes.

Some patients on methadone treatment have severe physical and mental health problems and are

socially isolated. Psychological treatments can be helpful for some but are often made mandatory for all. Encouraging education, training and employment and improving parenting should be important parts of opioid substitution treatment but rarely get the attention they deserve.

The benefits of opioid substitution include reduced overdose deaths, reduced deaths overall, reduced HIV infections, reduced hepatitis C infections, reduced drug use, reduced crime and improved social functioning.

Methadone treatment is one of the most frequently evaluated interventions in medicine. The World Health Organisation and other UN bodies with a major responsibility for illicit drugs policy have endorsed the treatment.

What are the side effects?

Common side effects of methadone include constipation, sweating, impotence in males (at higher doses),

loss of libido in males and females, and severe withdrawal symptoms when methadone is stopped abruptly.

Overdose deaths in children of parents on methadone treatment have occurred. Understandably, these cause considerable concern, resulting in vigorous efforts to minimize such deaths.

A controversial treatment

Methadone is often very controversial for decades after being introduced to a country. In Australia, the controversy over treatment is largely over,

although implacable opponents of harm reduction still occasionally question the treatment, Order methadone online.

Methadone treatment does not appeal to all users of heroin or prescription opioids, and may be inappropriate or ineffective for some. But it is better supported by evidence of effectiveness and is also very cost-effective.